发明名称 |
NOVEL ANTI-HUMAN THROMBOMODULIN MONOCLONAL ANTIBODY AND DIAGNOSIS OF VASCULAR ENDOTHELIAL INJURY BY ENZYME IMMUNOASSAY |
摘要 |
<p>PURPOSE:To diagnose vascular endothelial injury by using an anti-human thrombomodulin monoclonal antibody inhibiting an action of thrombomodulin accelerating activation of protein C with thrombin. CONSTITUTION:An enzyme immunoassay is performed by using an anti-human thrombomodulin monoclonal antibody having a inhibitory action on the action of thrombomodulin-accelerating activation on protein C with thrombin. Then, a determined value of substance binding to said monoclonal antibody among human thrombomodulin and its decomposed product existing in blood is compared with a determined value in blood of a healthy human to diagnose vascular endothelial injury. In said diagnosis, anti-human thrombomodulin monoclonal antibody having an action inhibiting the binding of thrombin to thrombomodulin is suitably co-used.</p> |
申请公布号 |
JPH03198793(A) |
申请公布日期 |
1991.08.29 |
申请号 |
JP19890336367 |
申请日期 |
1989.12.27 |
申请人 |
FUJI YAKUHIN KOGYO KK |
发明人 |
SUZUKI KOJI;UCHIJIMA EKUKO;KODAMA NOBUTSUGU;NAGAI MISAKO;MIKAWAYA KIYOUKO |
分类号 |
G01N33/53;C07K16/18;C12N5/10;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|