PROCESS FOR PRODUCING CRYSTALLIC HYDROCHLORIDES OF NEW BETA-LACTAME ANTIBIOTICS

摘要

The crystalline hydrochloride of the antibiotic 7 beta -[2 min -(R)-2 min -phenyl-2 min -aminoacetamido]-3-chloro-3-(1-carbadethiacephem)-4-carboxylic acid ("LY163892") is described. The crystalline hydrochloride is an antibiotic in its own right and is a valuable intermediate to the corresponding monohydrate form of LY163892. A process for preparing LY163892 crystalline hydrochloride is also provided.