| 摘要 |
PCT No. PCT/SU88/00271 Sec. 371 Date Aug. 18, 1989 Sec. 102(e) Date Aug. 18, 1989 PCT Filed Dec. 20, 1988 PCT Pub. No. WO89/06238 PCT Pub. Date Jul. 13, 1989.The compounds of the invention are 5'-phosphonates of 3'-azido-2',3'-dideoxynucleosides having the following general formula: <IMAGE> <IMAGE> where B is thymin-1-yl, cytosin-1-yl, adenin-9-yl, or guanin-9-yl. The compounds according to the present invention are selective inhibitors of replication of the human immunodeficiency virus in a culture of human lymphocytes.
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| 申请人 |
KHORLIN, ALEXANDR A.;TARUSOVA, NATALYA B.;DYATKINA, NATALYA B.;KRAEVSKY, ALEXANDR A.;BIBILASHVILI, ROBERT S.;GALEGOV, GEORGY A.;ZHDANOV, DECEASED, VIKTOR M.;BUKRINSKAYA, ADMINISTRATOR, BY ALISA G.;ZHDANOV, ADMINISTRATOR, BY VIKTOR V.;DERGACH, ADMINISTRATOR, BY DMITRY J.;KORNEEVA, MARINA N.;NOSIK, DMITRY N.;MAIOROVA, SVETLANA N.;SHOBUKHOV, VADIM M. |
发明人 |
KHORLIN, ALEXANDR A.;TARUSOVA, NATALYA B.;DYATKINA, NATALYA B.;KRAEVSKY, ALEXANDR A.;BIBILASHVILI, ROBERT S.;GALEGOV, GEORGY A.;ZHDANOV, DECEASED, VIKTOR M.;BUKRINSKAYA, ADMINISTRATOR, BY ALISA G.;ZHDANOV, ADMINISTRATOR, BY VIKTOR V.;DERGACH, ADMINISTRATOR, BY DMITRY J.;KORNEEVA, MARINA N.;NOSIK, DMITRY N.;MAIOROVA, SVETLANA N.;SHOBUKHOV, VADIM M. |
