ACYL DERIVATIVES

摘要

Acyl derivatives of the formula …… in which R denotes a one-ringed, carbocyclic aromatic group, a 5-membered, aromatic heterocyclic group which, as hetero ring members, contains an oxygen or sulphur atom or an imino group or lower alkylimino group and optionally one or two further nitrogen atoms, or a 6-membered, aromatic heterocyclic group which contains one to three nitrogen atoms as hetero ring members, R<1> denotes hydrogen or a 3-substituent which can be used in cephalosporin chemistry, A denotes lower alkylene or C3-7-cycloalkylene, which are optionally substituted by carboxyl, carbamoyl, lower alkylcarbamoyl or di(lower alkyl)carbamoyl, Q denotes lower alkylene or C3-7-cycloalkylene, which are optionally substituted by carboxyl, carbamoyl, lower alkylcarbamoyl or di(lower alkyl)carbamoyl, or the group -NR<2>- or -NR<2>NR<3>-, R<2> and R<3> each denotes hydrogen or lower alkyl, p and m denote the number 0 or 1, n denotes the number 0, 1 or 2, R<4> denotes hydrogen, lower alkanoyl or tri(lower alkyl)silyl, 2 radicals R<4> together denote diphenylmethylene, R<5> denotes hydrogen, lower alkyl, hydroxyl, lower alkoxy, halogen, nitro or the group -OCOR<7>, -OCOOR<7><1>, -N(R<7>)2, -NHCOR<7>, -NCOOR<7><1>, -COR<7>, -SR<7>, -SOR<7>, -SO2R<7>, -SO3H, -COOR<7> or -CON(R<7>)2, R<6> denotes hydrogen, lower alkyl or halogen, R<7> denotes hydrogen or lower alkyl and R<7><1> denotes lower alkyl, and the two groups -OR<4> are bonded via adjacent carbon atoms of the phenyl ring,… and easily hydrolysable esters and pharmaceutically acceptable salts of these compounds and hydrates of compounds of the formula I and of their esters and salts. The products have antibiotic activity, in particular antibacterial activity.