| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I [R<1> is H, (substituted) tetrahydrofuranyl or tetrahydropyranyl; R<2> is methyl or formylmethyl; R<3> is H or acyl; R<4> is H or OH]. EXAMPLE:3-Deoxydesmycosin shown by formula II. USE:An antimicrobial agent having excellent infection preventing action. PREPARATION:A tylosin derivative shown by formula III [R is H, OH-protecting group, (substituted) tetrahydrofuranyl or tetrahydropyranyl; R is methyl or (protected) formylmethyl; R is H or acyl or substituted silyl; A is (protected) carbonyl] is reduced with a reducing agent such as lithium aluminum hydride preferably under cooling.</p> |
