Fluoro-aryl cpds. prodn. with ortho electrophilic substituent

摘要

Prodn. of ortho-substd. fluoroaryl cpds. (I) comprises adding a strong base to a mixt. of a fluoroaryl cpd. and an electrophile. Also claimed is the use of o-fluoroarylboric acids, esters and anhydrides (I) i) for prodn. of corresp. o-fluorophenols by oxidative hydrolysis; ii) for prodn. of corresp. o-fluorohaloaryl cpds. by halogenation; or iii) as coupling components in transition metal cross-coupling reactions with halo- and perfluoroalkylsulphonyl cpds. Pref. cpds. (I) have the formula (I) R1 = H,F, alkyl, alkenyl or alkoxy with up to 18C or a mesogenic gp., W,X,Y = N, CH or CF; E = -CH2-R2, -CH(OH)-R2, -CH2-CH(OH)-R2 or a gp. of the formula (ii), (iii), (iv), (v), (vi) or (vii) R2 = 1-15C alkyl or a mesogenic gp. R3,R4 = H or alkyl, alkenyl or cycloalkyl with up to 10C or R3+R4 = -(CH2)n- or -CH2-CHR8-CH2-; R5 = aliphatic, cycloaliphatic, araliphatic or aromatic gp., R8 = alkyl, alkoxy or alkenyl with up to 18C or a mesogenic gp. Z = gp. of formula (VIII) n = 2-4.