5-lipoxygenase inhibitors

摘要

This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: <IMAGE> wherein R1 and R2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R3 is a) <IMAGE> wherein R4 is hydrogen or lower alkyl; b) <IMAGE> c) <IMAGE> wherein R6 and R7 may be the same or different and are alkyl of 1 to 4 carbon atoms; or d) <IMAGE> and the pharmaceutically acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.