PREPARATION OF 2-(2'-THIENYL)ALKYLAMINES AND DERIVATIVES THEREOF AND SYNTHESIS OF 4,5,6,7-THIENO[3,2-C]PYRIDINE DERIVATIVES THEREFROM

摘要

26790/26940-FF An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2'-thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.