| 摘要 |
<p>Muscarinic receptor antagonists, particularly useful in the treating of irritable bowel syndrome, of formula (I), and their pharmaceutically acceptable salts, wherein R is -CN or -CONH2; and R1 is a group of formula (a), (b), (c) or Het, where R?2 and R3¿ are each independently H, C¿1?-C4 alkyl, C1-C4 alkoxy, -(CH2)qOH, halo, trifluoromethyl, -(CH2)qNR?4R5, -SO¿2NH2, or -(CH2)qCONR?4R5; R4 and R5¿ are each independently H or C¿1?-C4 alkyl; q is 0, 1 or 2; r is 1, 2 or 3; X and X?1¿ are each independently O or CH¿2?; m is 1, 2 or 3; n is 1, 2 or 3, with the proviso that when the group -(CH2)m- is attached to the 3-position of the piperidine or pyrrolidine ring, n is 2 or 3; p is 0 or 1; and 'Het' is pyridyl, pyrazinyl or thienyl.</p> |
