| 摘要 |
The novel .DELTA.22- or .DELTA.23 -26,26,26,27,27,27-hexa-fluoro-1.alpha.,25-dihydroxycholecalciferol has vitamin D activity. It can be prepared by reacting ¢1R-¢1.beta.(R*),3a.alpha.,-4.beta.,7a.beta.!!-octahydro-1-¢6,6,6 -trifluoro-5-trimethylsilyloxy!- -5-trifluoromethyl-1-methyl -2-hexenyl!-7a-methyl-1H-inden- -4-one or ¢1R-¢1.beta.(R*),3a.alpha.,4.beta.,7a.beta.!!-octahydro-1-¢6,6,6-tri-fluoro -5-trimethylsilyloxy-5-trifluoromethyl-1-methyl -3-hexenyl!-7a-methyl-1H-inden-4-one, respectively, with ¢3S-(3.alpha.,5.beta.,Z)!-2-¢2-methylene-3,5 -bis¢(1,1-dimethyl-ethyl)dimethylsilyloxy!cyclohexylidene!ethyldiphenyl phosphine oxide and removing the silyl protecting groups. |
