| 摘要 |
<p>Peptides and other polymers which inhibit the binding of von Willebrand factor to platelet membrane glycoprotein Ib and/or glycoprotein Ib expressed on the surface of any cell of megakaryocytic lineage and methods of inhibiting platelet activation, adhesion of platelets to surfaces, platelet aggregation, or thrombosis. Also, recombinant DNA expression vectors encoding a peptide which inhibits binding of von Willebrand factor to platelet membrane glycoprotein Ib, said vector including a nucleotide sequence encoding the amino acid sequence from His?1 to Ala302¿, inclusive, of the amino terminal region of platelet membrane glycoprotein Iba, or any sequential subset thereof; mammalian host cells transformed by said vectors; and a process for producing a peptide having the identifying characteristics of the 45 kDa tryptic fragment of glycocalicin and a process for expressing the full length GPIBa polypeptide (His?1-Leu610¿) or a subfragment thereof.</p> |
