Process for the fermentative production of amino acids, especially L-lysine, microorganisms suitable therefor and recombinant DNA.

摘要

Provided according to the invention is a recombinant DNA which is replicable in Corynebacterium or Brevibacterium and is composed of vector DNA and of DNA sequences coding for the production of proteins with dapA activity and lysC activity. Microorganisms of the genus Corynebacterium or Brevibacterium which contain a recombinant DNA of this type are particularly suitable for obtaining amino acids, especially L-lysine. The DNA sequences are derived, in particular, from L-lysine-producing strains of the genus Corynebacterium or Brevibacterium, preferably from a mutant obtained by mutagenesis of Corynebacterium glutamicum ATCC 13032 with reduced feedback inhibition of aspartate kinase, such as from the strain DSM 5714. A particularly suitable transformed microorganism is formed by the Corynebacterium glutamicum strain DSM 5715.