摘要 |
<p>The present invention provides novel compounds, compositions, methods of their use and methods of their manufacture. The compounds of this invention are cyclic tetrapeptide tyrosyl substituted dipenicillanic acid opioid agonists that are selective for the delta-receptor. The compounds of the invention act as neurotransmitters or neuromodulators in the central nervous system central pain-suppressant system, to induce analgesia. The present invention provides new cyclic peptide derivatives which show improved potency and bioavailability as analgesic agents by central routes of administration.</p> |