| 摘要 |
<p>The compounds of the formula, <CHEM> wherein the ring A/ &cir& is a pyrrole ring which may be hydrogenated; - B/ &cir& - is a divalent cyclic or chain group which may be substituted; one of Q<1> and Q<2> is N, with the other being N or CH; W is a halogen or hydrogen atom or a group bonded to the bonding line with a carbon, nitrogen, oxygen or sulfur atom, provided that W is not -NH2; X is an amino, hydroxyl or mercapto group; Y is a hydrogen atom or a hydroxyl or amino group; Z is a straight-chain divalent group having a number of atoms of 2 to 5 composed of carbon atoms which each may be substituted, or carbon atoms which each may be substituted and one hetero atom which may be substituted; -COOR<1> and -COOR<2> each is the same as or different from the other and represents a carboxyl group which may be esterified, or salts thereof are provided. The compounds are produced by reacting compounds of the formula, <CHEM> wherein A/ &cir& , - B/ &cir& -, W, W, X, Y, Q<1> and Q<2> are the same as defined above, with compounds of the formula, <CHEM> wherein -COOR<1> and -COOR<2> are the same as defined above, and useful as anti-tumor agents.</p> |
