Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics

摘要

Novel blood sugar-lowering dihydropyridinelactones of the formula <IMAGE> in which R represents halogen, C1-C10-alkyl, C1-C10-alkoxy, C1-C10-alkylthio, C1-C10-alkylsulphinyl, C1-C10-alkylsulphonyl, cyano, C1-C6- mono- or polyfluoroalkyl, C1-C6-mono- or polyfluoroalkoxy or nitro, R1 represents hydrogen, halogen or C1-C10-alkyl or C1-C10-alkoxy, R2 represents a C1-C20 hydrocarbon radical which can optionally be interrupted or substituted, R3 represents hydrogen NH2, CHO, CN or a C1-C6 hydrocarbon radical which can be interrupted in the chain, and R4 represents a C1-C10-alkyl or C2-C10-alkenyl radical which can optionally be interrupted or substituted with the proviso that R is not CF3 if R2 represents C2H5.