PREPARATION OF PHARMACEUTICAL AND OTHER MATRIX SYSTEMS BY SOLID-STATE DISSOLUTION

摘要

A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composi- tion dissolved or dispersed in a first solvent and subsequently contacting t he solidified matrix with a second solvent that is sub- stantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix compo- nents being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix: