| 摘要 |
Formamidine compounds of general formula I <IMAGE> (I) in which: R1 represents H or C1-4 alkyl, R2 represents benzoyl, benzyl, or alphahydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom, R3 and R4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle, R5 represents hydrogen or C1-4 lower-alkyl or forms with R4 a double bond (-N=R4) in the case of pseudoaromatic heterocycles, n equals 0 or 1, A represents a linear or branched C1-4 alkylene chain, X represents hydrogen, halogen, C1-4 lower-alkyl, C1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed. The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.
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