发明名称 |
METHOD FOR PREPARING OF 6- N- EXOPHENYLCARBAMOYL- 3- (BETA- PHENYLISOPROPYL) SIDNONIMINE |
摘要 |
This compound is used for medical purposes as a biologically active substance with a stimulating effect on the nervous system and is commonly known under the generic name of mesocarb. The method uses a simplified flow diagram, which ensures increased yield rates in terms of final product. The method involves carrying out a cyan-methylation of β-phenyl-iso-propylamine, followed by a nitrosification in an acetic acid medium in the presence of catalytic amounts of potassium bromide and subjecting the product to an intramolecular cyclization until 3-/ β-phenyl isopropyl/ sydnonimine is obtained.The latter is settled using an aqueous solution of nitrate ions, the nitrate obtained made to react with phenyl isocyanate in a chloroform medium in the presence of triethyl amine.
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申请公布号 |
BG48860(A1) |
申请公布日期 |
1991.06.14 |
申请号 |
BG19890089359 |
申请日期 |
1989.07.27 |
申请人 |
TEKHNOLOGICHEN KHIMIKO-FARMATSEVTICHEN KOMBINAT |
发明人 |
DRANDAROV, KONSTANTIN B.;PASKOV, VLADIMIR D. |
分类号 |
C07D271/04;(IPC1-7):C07D271/04 |
主分类号 |
C07D271/04 |
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