New substd. 3-amino-sydnonimine derivs.

摘要

Substd. 3-amino sydnonimine derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new. In (I), A= S or SO2; R1= COR2 or H; R2= 1-4C alkyl, 1-4C alkoxy (1-4X)alkyl, 1-4C alkoxy, 5-7C cycloalkyl, Ph (this last opt. mono, di or tri-substd. by halogen, 1-4C alkyl and/or 1-4C alkoxy). 3 cpds. (I) are specifically claimed, namely 3-(3,3-dimethyl-tetrahydro -1,4-thiazin-4-yl)-sydnonimine hydrochloride, N-p-arisoyl-3-(3,3-dimethyl tetrahydro-1,4-thiazin-4-yl sydnonimine (and its pharmaceutically acceptable salts, esp. hydrochloride) and 3-(3,3-dimethyl)-1,4 -tetrahydro-thiazine-1,1 -dioxid-4-yl)sydnonimine hydrochloride (Ia).