A chemical reaction apparatus is disclosed which comprises endless travelling belt(s) disposed to support in place a multiplicity of juxtaposed reaction containers having the axes thereof falling in a plane inclined from the horizontal plane and adapted to travel in a substantially horizontal direction perpendicular to the axes of the reaction containers; endless retaining belts disposed adjacent and not contiguously to the aforementioned travelling belts and provided with a multiplicity of teeth projecting up as at fixed regularly spaced intervals slightly greater than the diameters of the reaction containers so as to enable the reaction containers accommodated in the intervening spaces between the teeth to be held in fixed positions in an arrayed pattern; a base adapted to support in place the bottoms of the aforementioned reaction containers rotated about the axes thereof in an inclined state by the aforementioned travelling belts and the aforementioned retaining belts; and a drive mechanism for intermittently driving the aforementioned retaining belts and thereby effecting pitched movement of the aforementioned reaction containers.