发明名称 |
Pradimicin derivatives. |
摘要 |
<p>The present invention provides pradimicin analogs of formula (II) which exhibit improved water solubility relative to parent compounds. These novel agents are useful in treatment of fungal infections. <CHEM> wherein R<1> is selected from the group consisting of H, methyl, and hydroxymethyl, and when R<1> is methyl or hydroxymethyl, the resulting amino acid has the D-configuration; R<2> is H or beta -D-xylosyl; R<3> is H or methyl; and R<4> is selected from the group consisting of (C2-5)alkenyl; (C2-5)alkynyl; substituted (C1-5)alkyl; substituted (C2-5)alkenyl; wherein the substituent for both the alkyl and alkenyl is a group selected from the group consisting of, carboxy, (C1-5)alkoxycarbonyl, carbamyl, (C1-5)alkylcarbamyl, di(C1-5)alkylcarbamyl, and sulfonyl; (C1-5)alkanoyl substituted with a group selected from the group consisting of amino, (C1-5)alkylamino, and di(C1-5)alkylamino; L-glutamyl; formyl; benzyl; and p-tolylsulfonylcarbamyl; or a pharmaceutically acceptable salt thereof.</p> |
申请公布号 |
EP0428132(A1) |
申请公布日期 |
1991.05.22 |
申请号 |
EP19900121709 |
申请日期 |
1990.11.13 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KAMACHI, HAJIME;IIMURA, SEIJI;OKUYAMA, SATSUKI;ABURAKI, SHIMPEI;NAITO, TAKAYUKI;UEDA, YASUTSUGU;CRAST, LEONARD B., JR.;MIKKILINENI, AMARENDRA B. |
分类号 |
C07H15/24;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P31/04;C07H15/244 |
主分类号 |
C07H15/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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