FREMGANGSMAATE TIL FREMSTILLING AV CARBAPENEMDERIVATER.

摘要

Disclosed is a new and more efficient process for producing carbapenem antibiotic derivatives having a 2- substituent of the general formula S-A-R<14> wherein A represents cyclopentylene, cyclohexylene or C2- C6 alkylene optionally substituted by one or more C1-C4 alkyl groups and R<14> represents a quaternized nitrogen-containing aromatic or non-aromatic heterocycle attached to A through a quaternary nitrogen atom. The carbapenems produced by this process are of the formula R<8> being hydrogen and R<1> being hydrogen or one of various defined organic groups or R<1> and R<8> together completing a ring and R<2> being hydrogen, an anion or a protecting group. The starting materials are of the formula and H-S-A-R<14> L being a leaving group and R<2> being a protecting group.