| 摘要 |
Prepn. of imidazolyl-vinyl ether cpds. of formula (I) and their acid addition salts comprises reaction of a ketone of formula (II) with an ether of formula (III) in an aq. soln. of a strong base and in the presence of a second liquid phase consisting of a water immiscible organic solvent and a quaternary tetrealkylammonium salt as phase transfer catalyst. In the formula Im = IH - imidazol-1-yl; R = H or Me, Ar1, Ar2 = phenyl opt. substd. by 1 or 2 Cl; Alk = 1-3C alkyl; Z = a gp. removable by a base. The phase transfer catalyst is methyltrioctylammonium chloride. The base is NaOH and the organic solvent is toluene. (I) are antibacterials and antifungals known from me.g. EP0008804. This process is cheaper, technically easier and gives better yeilds than the process described in EP0069754. The products are almost exclusively of the Z-configmation which is more effective against bacteria and fungi.
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