| 摘要 |
Inhibiting platelet aggregation and antagonizing thromboxane A2 with new 2-halogen-substituted N-indolyethyl-sulphonamides of the formula <IMAGE> (I) in which R1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl having up to 8 carbon atoms, or represents straight-chain or branched alkyl having up to 8 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms, which is optionally substituted by carboxyl, halogen, alkoxy or alkoxycarbonyl having in each case up to 8 carbon atoms, cyano or hydroxyl, or represents a group of the formula -S(O)n-R5,-NR6R7 or -OR8 represents straight-chain or branched alkyl having up to 10 carbon atoms, which is optionally substituted by halogen, phenyl, hydroxyl or cyano, or represents aryl having 6 to 10 carbon atoms, which is optionally substituted by up to 5 identical or different substituents from the group comprising halogen, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, alkyl, alkoxy, alkoxycarbonyl or alkylthio having in each case up to 8 carbon atoms, hydroxyl, carboxyl, phenyl, phenoxy, benzyloxy and benzylthio, or by a group of the formula -NR6R7, R3 represents halogen, R4 represents hydrogen or straight-chain or branched alkyl having up to 8 carbon atoms, or represents phenyl and m represents one of the numbers 2, 3 or 4, and salts thereof.
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