发明名称 |
Stabile polymorphic form of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide and the process for its preparation. |
摘要 |
<p>Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).</p> |
申请公布号 |
EP0426468(A2) |
申请公布日期 |
1991.05.08 |
申请号 |
EP19900311963 |
申请日期 |
1990.11.01 |
申请人 |
ORION-YHTYMAE OY |
发明人 |
PIPPURI, AINO KYLLIKKI;HONKANEN, ERKKI JUHANI;HAARALA, JORMA VEIKKO |
分类号 |
C07C253/30;A61K31/275;A61P25/28;C07C253/34;C07C255/41;C07C255/59;(IPC1-7):C07C255/41 |
主分类号 |
C07C253/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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