| 摘要 |
Bismuth is used to mfr. a medicament for the treatment of infections gastrointestinal disorders in humans and animals, the treatment comprising administering bismuth at 50-5,000 mg/day for 3-56 days and also administering an antimicrobial daily e.g. for 1-21 days in an amt. of 100-10,000 mg/day. A compsn. for the treatment of gastrointestinal disorders comprises 50-5,000 mg of bismuth and 100-10,000 mg of an antimicrobial. The bismuth is pref. administered in the form of salt e.g. the aluminate, subcarbonate, subcitrate, citrate, subgalate, subnitrate, tartrate or salicylate, or tripotassium dicitrato bismuth. The stated wt. quantities are of elemental bismuth, so the actual wt. of bismuth-contg. cpd. will be greater. The pref. amt. of bismuth is 500-1,500 mg. daily. For a non-ulcerative disorder the bismuth is pref. administered for 3-21 days and for a peptic ulcer disease it is pref. administered for 14-56 days. Pref. treatment with the bismuth starts before treatment with the antimicrobial e.g. 1-21 days before initial administration of the antimicrobial, and it may completely precede administration of the antimicrobial. Pref. the bismuth is administered orally and the antimicrobial is administered by any suitable route but most pref. orally. Pref. the antimicrobial is administered for 1-14 days. Suitably it is an antibiotic but it may also be e.g. a sulphonamide or a nitrofuran. Pref. cpds. include penicillin, erythromycin, doxycycline, metronidazole, tinidazole, amoxycillin, ampicillin and nitrofurantoin. Pref. compsns. contain 250-1000 mg. of bismuth and 100-1000 mg. of antimicrobial. Carriers and excipients are conventional. In a pref. compsn. a capsule contains the bismuth cpd. as particles and seperate, enterically coated antimicrobial particles. A diagnostic test is pref. performed on a patient to determine a suitable dose of a suitable antibacterial. |
