| 摘要 |
<p>Compositions that disrupt microvascular endothelial and epithelial cell tight junctions, and methods of use, are disclosed. Such compositions comprise agents that inhibit the binding to such cells of cell adhesion molecules. Such inhibitor agents include cell adhesion molecules, fragments of cell adhesion molecules that encompass a cell-binding domain such as HAV, and antibodies directed against cell adhesion molecules and fragments thereof. Also disclosed are drug delivery compositions comprising a therapeutic drug conjugated to an agent that disrupts cell tight junctions.</p> |
