| 摘要 |
PURPOSE:To obtain an antitumor agent, composed of a conjugant of a liposome containing a lymphotoxin to a monoclonal antibody and capable of exhibiting powerful tumor proliferation inhibitory effects as compound with those in single use of the lymphotoxin. CONSTITUTION:A liposome pharmaceutical obtained by containing a lymphotoxin(LT) in a liposome and then linking the resultant LT-containing liposome to a monoclonal antibody(e.g. monoclonal antibody against an antigen held by cancer cells). Methods for linking the antibody to a membranous lipid of the liposome, modifying the antibody, introducing hydrophobic groups and thereby integrating the antibody onto liposome membranes; integrating a polymer, having hydrophobic groups and rich in reactivity onto the liposome membranes and linking the aforementioned polymer to the antibody, etc., are cited as a method for linking both. |
