发明名称 NEW SUBSTANCE, DAVALLIA LACTONE
摘要 NEW MATERIAL:A compound of the formula showing the following physicochemical properties. Molecular weight: 464; Molecular formula: C25H20O9; Mass spectrometric analysis: negative FAB-MSm/z 463 [M-H]-; Specific rotatory power: [alpha]D =+348 deg. (C=0.5, methanol); solubility: soluble in pyridine and methanol and sparingly soluble in water and n-hexane; Color reaction: dark blue coloring by FeCl3 reagent, Color: yellow acidic substance, etc. USE:An anti-cancer agent. PREPARATION:A semi-dried rhizome of a plant belonging to Davallia genus, especially Davallia meriesii Moor is subjected to extraction using an organic solvent such as ethanol or acetone or a mixture solution of an organic solvent and water. From the resultant extract, the objective new substance is isolated using a purification method consisting of a combination of filtration, condensation, extraction, washing, drying, recrystallization and various chromatography.
申请公布号 JPH0390084(A) 申请公布日期 1991.04.16
申请号 JP19890225124 申请日期 1989.08.31
申请人 KYOWA HAKKO KOGYO CO LTD;KIKUCHI TORU 发明人 NAKANO HIROFUMI;TAMAOKI TATSUYA;KIKUCHI TORU;SAI SHIYOUHIN;TEZUKA YASUHIRO
分类号 C07D493/04;A61K31/365;A61K36/00;A61P35/00 主分类号 C07D493/04
代理机构 代理人
主权项
地址