| 发明名称 |
ANTISENSE OLIGONUCLEOTIDES TO C-ABL PROTO-ONCOGENE |
| 摘要 |
Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-abl gene. These ''antisense'' oligonucleotides are hybridizable to the c-abl mRNA transcript. Such oligonucleotides are useful in inhibiting proliferation of myeloid cells, particularly in myelo-proliferative disorders such as chronic myelogenous leukemia. |
| 申请公布号 |
AU6410790(A) |
申请公布日期 |
1991.04.08 |
| 申请号 |
AU19900064107 |
申请日期 |
1990.08.29 |
| 申请人 |
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCAT |
发明人 |
BRUNO CALABRETTA;ALAN M. GEWIRTZ |
| 分类号 |
A61K31/70;A61K38/00;A61P35/00;A61P35/02;C07H21/04;C07K14/82;C12N9/12;C12N15/113 |
主分类号 |
A61K31/70 |
| 代理机构 |
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代理人 |
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| 地址 |
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