| 摘要 |
CHEWABLE SPRAY DRIED SPHEROIDAL MICROCAPSULES AND WAX COATED MICROCAPSULES AND METHODS FOR PREPARING SAME The present invention pertains to a spray dried spheroidal microcapsule under about 150 microns in diameter which comprises (a) a medicament present in an amount from about 1% to about 90%, by weight of the microcapsule composition, (b) a film forming polymer present in an amount from about 8% to about 90%, by weight of the microcapsule composition, (c) a plasticizing agent in an amount from about 5% to about 30%, by weight of the film forming polymer In another embodiment, the invention is directed at a spheroidal coated microcapsule under about 850 microns in diameter which comprises at least one spray dried spheroidal microcapsule core under about 150 microns in diameter and a coating layer over the core, wherein the coating layer comprises in percentages by weight of the coating layer composition (a) an edible material having a melting point from about 25.degree. C. to about 100.degree. C. selected from the group consisting of (i) fatty acids having an iodine value from about 1 to about 10, (ii) natural waxes, (iii) synthetic waxes, and (iv) mixtures thereof, present in an amount from about 80% to about 99.5%, and (b) a surface active agent present in an amount from about 0.5% to about 20%.
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