Substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides), process for their production as well as X-ray contrast media containing them

摘要

The invention relates to new substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilines), of general formula I <IMAGE> (I) in which R1 means a hydrogen atom, a C1-C4 alkyl radical or R2, wherein R1 and R2 are the same or different, R2 means a straight-chain or branched-chain C21 PROPORTIONAL C8 monohydroxyalkyl radical or polyhydroxyalkyl radical, R3 means a hydrogen atom, a C1-C4 alkyl radical or R2, R4 means a hydrogen atom or a C1-C4 alkyl radical, and n=1 or 2. The new nonionic compounds of formula I because of their good pharmacological and physiocochemical properties are outstandingly suitable as radiopaque substances in X-ray contrast media for use in all the fields of applications of X-ray contrast media.