Compounds and process for measuring c-reactive protein

摘要

New compounds are described of the formula: <IMAGE> wherein Z is selected from <IMAGE> each x is selected from <IMAGE> +TR <IMAGE> n is an integer from 1-10; each Y is selected from hydrogen, -NH2, -COQ, -COOQ, -COONHQ, -COOH, -OH, W, halogen and Q; wherein each Q is independently selected from substituted and unsubstituted lower alkenyl and lower alkyl and wherein the substitutuents are selected from -NH2+L, halogen, -OH, and -COOH; D is selected from hydroxy, hydrogen and -NH2; and W is selected from <IMAGE> +TR <IMAGE> wherein each R is independently selected from hydrogen and lower alkyl; R' is selected from ethylene, propylene, isopropylene and phenylene; M is selected from chlorine and hydroxy; A is selected from hydrogen, lower alkyl, lower alkenyl, cycloalkyl, and phenyl; (B) is selected from <IMAGE> -CO-, -NHCO-, -O-, -COO-, -N=N-, or represents a confugate bond; L1 and L2 are selected from hydroxy substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl, or phenyl; providing L2 can be a conjugate bond. These compounds have specific utility in a process, for measuring c-reactive protein by binding with c-reactive protein and acting to release metal ions and/or inhibit the flow of the metal ion complex under electrochemically measurable conditions.