A hypodermic syringe including a connector member for securing the proximal end of a hollow needle to the distal end of the syringe and a hollow protective elastomeric sleeve having a closed end and an open end, the open end having an inside diameter which is less than the outside diameter of the connector member. A shoulder is formed about the exterior of the open end of the protective sleeve forming a resilient deformable end section on the sleeve which is deformable to grippingly engage the outside of the connector member. An enlarged hollow truncated conical shaped guide member is secured to the sleeve to guide the sharp pointed hollow needle into the open end of said elastomeric sleeve to shield the hand of a health care worker against needle stick injuries. Locking lugs on the inner wall of the protective sleeve between opposite ends thereof detachably engage a non-circular end of the connector member when the conical shaped end of the connector member is urged into deforming frictional engagement with the inner wall of said sleeve.
