| 摘要 |
Quaternary ammonium salts of natural polysaccharides possessing hypocholesterolemic activity, of the following general formula: X(-) (I) in which A represents the monomer unit of a natural polysaccharide, m is a whole number between 100 and 1000, n is a whole number between 0 and 10, B is O or S or NH or NR' where R' is an acyl and preferably an acetyl, R is a linear alkyl radical of 1-4 carbon atoms, and X(-) is an anion such as Cl-, Br-, I-, HSO4-, CH3O-SO3-, NO3- or the negative ion of a pharmaceutically acceptable organic acid. Said salts are prepared by reacting a pretreated natural polysaccharide with a quaternary ammonium salt functionalised at one of its ends with an epoxy group. |
