| 摘要 |
89/VJClA 17970 TITLE OF THE INVENTION 6- AND/ OR 7-SUBSTITUTED-1,2,3,4,4a,9b-HEXAHYDRO-8-HYDROXYDIBENZOFURAN-3-OLS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS Positions 7-and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described. These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful in the treatment of a variety of inflammatory conditions.
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