| 摘要 |
<p>A new intermediate, an optically active (1R,5S,6S,7R)-6-tert-butyldiphenylsilyloxymethyl-7-hydroxybicyclo[3.3. 0]octan-3- one (I) having high optical purity, is useful for the synthesis of an optically active carbacyclin and an optically active pentalenolactone E methyl ester. Compound (I) is also an intermediate compound useful in improving the optical purity of (1R,5S,6S,7R)-3,3-ethylenedioxy-6-hydroxymethyl-7-(2'-tetrahydropyrany loxy)bicyc lo[3.3.0]octane. Compound (I) is prepared by reacting (1R,5S,6S,7R)-3,3-ethylenedioxy-6-hydroxymethyl-7-(2'-tetrahydropyrany loxy)bicyc lo[3.3.0]octane with tert-butylchlorodiphenylsilane in the presence of a base and removing the ethylenedioxy and tetrahydropyranyl groups of the resultant compound under acid conditions. <CHEM> e</p> |
