3-(1-Substituted-4-piperazinyl)-1H-indazoles, a process for their preparation and their use as medicaments.

摘要

This invention relates to 3-(1-substituted-4-piperazinyl)-1H-indazoles having the following formula <CHEM> wherein R1 is hydrogen, lower alkyl, arylloweralkyl, acyl, cycloalkylloweralkylene, and phenylsulfonyl; and R2 is hydrogen, lower alkyl, hydroxyloweralkyl of the formula &lparstr& loweralkylene &rparstr& OH , arylloweralkyl, acyl, cycloalkylloweralkylene, <CHEM> where Z is selected from hydrogen, halogen, loweralkoxy, CF3, NO2, and NH2; <CHEM> where Z is as defined above; <CHEM> where Z is as defined above; <CHEM> where R3 and R4 are each independently hydrogen and loweralkyl; <CHEM> where Z is as defined above; <CHEM> where R min and R sec are each independently hydrogen and loweralkyl; X is hydrogen, loweralkyl, hydroxyl, halogen, loweralkoxy, CF3, NO2 and amino; n is an integer of 1 to 4, with the further proviso that R2 is not loweralkyl when R1 is hydrogen or acyl and X is chloro; the pharmaceutically acceptable acid addition salts thereof and where appropriate the geometric isomers, the stereoisomers and racemic mixers thereof. The compounds of this invention display utility as analgesic and antipsychotic agents.