METHOD OF N-METHYL-N-(2-CYANOPHENYL)CARBAMOYL CHLORIDE PREPARATION

摘要

The invention concerns a method of production of N-methyl-N-(2-cyanphenyl)carbamoyl chloride of formula I by reaction of 1-methylisatin-3-oxime of formula II with thionyl chloride in excess without the presence of solvent at 40 to 50 degrees C. The substance of formula I is re-crystallised from cyclohexane after distillation off of un-reacted thionyl chloride. The substance of formula I is used for synthesis of 3-substituted 1-methyl-1-(2-cyanphenyl)urea, which has pesticide action, or is used as an intermediate product for synthesis of substituted quinazoline with applications in pharmacology (antimalarial, sedative, antifollicular) and in agriculture (pesticides, growth stimulators).<IMAGE>