发明名称 |
FOERFARANDE FOER AVLAEGSNING AV SYRE FRAON 7 -ACYLAMINO-3-CEFEM-4-KARBOXYLSYRA-1-OXIDDERIVAT. |
摘要 |
Multi-step one-pot process for the preparation of inter alia 7 beta -amino- and 7 beta -acylamino-3-substituted methyl-3-cephem-4-carboxylic acid derivatives starting from 7 beta -acylamino-3-methyl-3-cephem-4-carboxylic acid 1 beta -oxide derivatives, comprising a new process for deoxygenation of generally 7 beta -acylamino-3-cephem-4-carboxylic acid 1-oxide derivatives optionally substituted in the 7 alpha -position, which can be applied as single step or can be incorporated in multistep processes without isolation of intermediates. …<??>The deoxygenation involves the use of phosphorus pentachloride and an olefine for removal of chlorine at least in part by addition to carbon-carbon double bond. …<??>Preferred aspects are lasting protection of reactive substituents by silylation and preparation on industrial scale of generally 7 beta -amino-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids starting from suitably 7 beta -phenyl-acetamido-3-methyl-3-cephem-4-carboxylic acid 1 beta -oxide. |
申请公布号 |
FI83223(B) |
申请公布日期 |
1991.02.28 |
申请号 |
FI19840003926 |
申请日期 |
1984.10.05 |
申请人 |
GIST-BROCADES N.V. |
发明人 |
VERWEIJ, JAN;GROOTVELD, HERMAN HENDRIK;HIRS, HENRI GERARD JULIUS;VAN VEEN, GERARDUS JOHANNES;KALTER, JAN;HENNIGER, PETER WOLFGANG |
分类号 |
A61K31/545;C07D;C07D501/00;C07D501/04;C07D501/18;C07D501/20;C07D501/22;C07D501/36;C07D501/38;C07D501/42;C07D501/46;C07D501/57;C07D501/58;C07F7/18 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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