发明名称 Macrocyclic compounds.
摘要 <p>There are described compounds of formula I, &lt;CHEM&gt; wherein R&lt;1&gt; represents H or OH; R&lt;2&gt; represents H; in addition, R&lt;1&gt; and R&lt;2&gt; may together represent a second carbon-carbon bond between the carbon atoms to which they are attached; R&lt;3&gt; represents OH or OCH3; X represents O or (H,OH); and Y represents O or N-OR&lt;4&gt;, in which R&lt;4&gt; represents H or alkyl C1-6; provided that when R&lt;1&gt; is OH, R&lt;2&gt; is H and X is O, then Y does not represent O. Processes for their production and compositions containing them, eg for use as immunosuppressive agents, are also described.</p>
申请公布号 EP0413532(A2) 申请公布日期 1991.02.20
申请号 EP19900308853 申请日期 1990.08.10
申请人 FISONS PLC 发明人 DONALD, DAVID KEITH;HARDERN, DAVID NORMAN;COOPER, MARTIN EDWARD;FURBER, MARK
分类号 C07D498/18;A61K31/445;A61P37/06;C07H19/01 主分类号 C07D498/18
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