METHOD OF PRODUCING DIASTEREOMER OF N-4[2-(2-AMINO-4-HYDROXY-5,6,7,8-TETRAHYDROPYRIDO[2,3-]PYRIMIDINE-6-YL-)ETHYLBENZOYL-L-GLUTAMIC ACID

摘要

The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d] -pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid are antineoplastic agents. The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.