摘要 |
NEW MATERIAL:A peptide (salt) expressed by the formula [A is H, H-His, H-Cys(Cys)-His, H-Phe-Cys(Cys)-H is or H-Tyr-Phe-Cys(Cys)-His]. USE:An assistant remedy in acute arterial hypotension and shock, agent for prolonging action of local anesthesia and remedy for megrim and orthostatic hypotension. PREPARATION:For example, operation for binding an amino acid protected by-amino group, etc., to 4-(oxymethyl)-phenylacetoamidemethyl resin, etc., used as an insoluble supporting body from C-end side according to amino acid sequence of peptide by a solid phase method and then removing the amino group is successively carried out to synthesize a peptide resin and then the resultant peptide resin is treated with hydrogen fluoride and elimination from the peptide resin and removal of the protecting group are carried out to provide the peptide expressed by the formula. |