| 摘要 |
NEW MATERIAL:A compound of the formula (R is pyridyl, amino, substituted amino, phenoxyalkyl or phenyl that may have substituents on the nucleus). USE:It is used for treating and preventing human and animal diabetes, arteriosclerosis, and ischemic cardiopathies. This compound improves hypercaloriemia accompanied by diabetes and arteriosclerosis to maintain normal metabolism in a living body. PREPARATION:An acid reactive derivative such as an acid halide, acid anhydride, when necessary, cyanate or isocyanate is made to act on ascochlorin, preferably in a solvent in the presence of a condensation agent such as pyridine or dimethylaniline to produce 4-0-acyl derivative of ascochlorin of the formula. |
