摘要 |
<p>This invention relates to a sulfated polysaccharide D-HG, prepared by depolymerizing FGAG (an extract from the parietes of a sea cucumber comprising a sulfated polysaccharide having a heparinlike action) or its salt and having the following physicochemical properties, pharmaceutically acceptable salts thereof, a method for preparing the same, and drugs for treating diffuse intravascular coagulation (DIC) and thrombosis containing the same as the active ingredient: (1) molecular weight: 3000 to 42000 according to HP GPC; (2) form: white, amorphous and highly hygroscopic powder; (3) solubility: soluble in water and insoluble in organic solvents such as ethanol and acetone; (4) specific rotation: (a); (5) color reaction: Elson-Morgan reaction (+); carbozole-sulfuric acid reaction (+); cysteine-sulfuric acid reaction (+); orcinol-hydrochloric acid reaction (+); azure A metachromasia reaction (+); (6) compositional analysis: galactosamine : glucuronic acid : fucose : sulfate radical = 1 : 0.8 +/- 0.2 : 0.85 +/- 0.15 : 3.4 +/- 0.9.</p> |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD.;KOTAI KASEI CO., LTD. |
发明人 |
FAN, HUI-ZENG 508, GATE 3 YAO YAN LI;YU, SONG 706, BUILDING 4 CADRE SANATORIUM;YAMANAKA, ETSUJI;NUMATA, KAZUHIRO;OKA, TOSHINORI 14-17, AZA SEICHO SHOZUI AIZUMICHO;SUZUKI, NORIHIKO 501, KAGASUNO KAWAUCHICHO;MURANAKA, YOSHIYUKI 682-5, ENOKIZE KAWAUCHICHO |