ACRYLIC AMIDE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE IN MEDICINE

摘要

NOVEL ACRYLIC AMIDE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPSITIONS CONTAINING THE SAME AND THEIR USE IN MEDICINE of the disclosure Novel acrylic amide derivative of the formula (I) wherein R1 represents a hydrogen or a halogen atom or a C1-4alkyl, a C1-4alkoxy or a nitro group. n is an integer of 0 to 2, A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C1-4alkyl group or is amidated; or A represents a group of formula (II) wherein R2 is a hydrogen atom or a phenyl, a C1-4alkyl or a C1-4alkoxycarbonyl group, and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.