| 摘要 |
NEW MATERIAL:Compound of formula I {R<1> and R<2> are R, chloro, etc.; R<3> and R<4> are H or 1-8C alkyl; Y is CH2, CH=CH, etc.; Z is formula II or III [Q is C(O), CH(OH), etc.; W is C(O), C(R<11>) (OH) (R<11> is H or 1-3C alkyl), etc.; R<12> is H or R<14> (R<14> is alkyl of hydrolyzable alkylester part), etc.], R<5> is H or 1-8C alkyl}. EXAMPLE:(E)-7-[4'-(4''-fluorophenyl)-2'-methyl-6'-(1''-methylethylthie no[2,3- b]pyridine-5'-yl]-3,5-dihydrohept-6-enoic acid. USE:An antihyperlipoproteinemia agent and an antiatherosclerosis agent. PREPARATION:A compound of formula IV (R<21> is 1-4C lower alkyl) is initially subjected to reduction, oxidation and acid hydrolysis in order and the resultant compound of formula V is subsequently added to a double anion of an acetoacetic ester. The obtained compound of formula VI is then reduced using a reducing agent.
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