| 摘要 |
NEW MATERIAL:A biphenyl derivative of formula I [R<1> is (substituted) amino or (substituted) nitrogen-contg. heteromonocyclic group; R<2> is lower alkyl; R<3>-R<8> are such that two of them are H, the rest being lower alkoxy, or lower alkylencdioxy is formed with adjacent two groups are mutually bound] or its salt. EXAMPLE:N-(2-methyl-3-hydroxypropane-2-yl)-5,6-methylenedioxy-2.-(2 methylphenyloxycarbonyl)-4',5'-dimethoxy-2-biphenylcarboxamide. USE:Useful as a therapeutic or preventive agent for hepatopathy. It is preferable to be orally administered. PREPARATION:For example, a biphenylcarhoxylic acid compound of formula II is condensed with a compound of formula III to obtain the objective compound of the formula I. The other objective compound of formula II can be obtained by reducing a compound of formula IV (Y is lower alkylidene). |
