发明名称 |
Improved synthesis of beta-lactams using a metal compound. |
摘要 |
<p>A synthesis of trans- beta -lactams with an easily convertible group on the C-4 carbon atom of the azetidinone ring comprising a condensation reaction of a metal enolate with an imine with a heterocyclic group or a diimine is provided. Furthermore, new chiral beta -lactams and an enantioselective synthesis of beta -lactams using a chiral imine or alpha -diimine are provided. Also new chiral substituted amino propionic ester metal compounds and new chiral amino acid compounds and processes for the preparation thereof are provided.</p> |
申请公布号 |
EP0404267(A1) |
申请公布日期 |
1990.12.27 |
申请号 |
EP19900201621 |
申请日期 |
1990.06.20 |
申请人 |
RIJKSUNIVERSITEIT UTRECHT |
发明人 |
VAN KOTEN, GERARD;VAN DER STEEN, FREDERIK HENDRIK;JASTRZEBSKI, JOHANN TOENS BARTHOLD HEINRICH;KLEIJN, HENK;BRITOVSEK, GEORGE |
分类号 |
C07B53/00;C07C237/04;C07D205/085;C07D401/04;C07D403/04;C07D405/04;C07D409/04;C07F3/06;C07F5/02;C07F5/06;C07F7/10;C07F7/22;C07F7/28 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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