Neue Phenyl-azolyl-fettsaeure-derivate,Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

摘要

Antimicrobial aminoalkyl phenyl-azolylalkanoates and N-(aminoalkyl)phenyl-azolylalkanamides and salts thereof are prepared by treatment of the corresponding phenyl-halo-alkanoate or alkanamide with an azolyl compound or saalt thereof, treatment of the corresponding phenyl-hydroxyalkanoate or phenyl-hydroxyalkanamide with an azole compound under dehydration conditions or with a thionyl-bis-azole, or transesterification or amidation of a (lower)alkyl phenyl-azolylalkanoate. A typical embodiment is diphenyl-imidazolyl-acetic acid 1-dimethylamino-2-propyl ester.